However Dr Ormerod, Dr Weatherill, Alun Morris, Lizzie Hopkirk and Sister Brigid all first appeared in Heartbeat and remained in The Royal until the end.
The show largely avoided political topics, though the was briefly featured in one episode, and its main themes were the conflict between progressive and conservative social ideals, and the ethical challenges and social changes faced by the hospital's staff, reflecting the setting in the 1960s.
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By the end of the third series, however, the show's ties to Heartbeat had been discontinued.
The spin-off focused on the same settings of the main show, but set in the present day with a new cast of characters.
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