In her first match, she rallied from 4—6, 1—4 down to defeat Alisa Kleybanova 4—6, 6—4, 6—0.
Janković's next tournament was the 2010 Toray Pan Pacific Open, where was seeded No.
She was defeated by fellow Serb Ana Ivanović in the fourth round, losing 4—6, 2—6.
With this, Serbia was placed in World Group I again.
In the first round, she defeated Klára Zakopalová 7—5, 7—5, but eventually fell in the third round against fellow Serbian player Bojana Jovanovski in three sets, Janković lost 6—4, 2—6, 2—6.
In her next Fed Cup match, she defeated reigning French Open Champion Svetlana Kuznetsova 6—3, 4—6, 6—3.